ARMO BioSciences, Inc., a clinical-stage biotechnology company, today announced positive clinical data from a Phase 1 clinical trial of AM0010, a PEGylated form of recombinant human interleukin-10 (PEG-rHuIL-10) at the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL.
“We are pleased to present the positive results of our Phase 1 dose escalation study, demonstrating the promise of ARMO’s immuno-oncology agent AM0010 to harness the body’s capability to arm itself against tumor cells,” said Peter Van Vlasselaer, President and CEO of ARMO. “We have now enrolled over 200 patients across 12 indications in the expansion portion of the Phase 1 study. We see sustained stable disease extending longer than a year, and objective responses (CR and PR) in heavily pre-treated patients resulting from treatment with AM0010 as a single agent and in combination with either anti-PD-1 antibodies or standard of care chemotherapy. Importantly, AM0010 induces a comprehensive T cell activation signature in serum cytokines, and increases the quantity and activity of PD1+ CD8+ T-cells in the blood and in the tumors of patients, indicating that AM0010 effectively stimulates the immune system of cancer patients, irrespective of their prior treatment.”